Behavioral Changes as the Earliest Clinical Manifestation of Progressive Supranuclear Palsy
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چکیده
منابع مشابه
Behavioral Changes as the Earliest Clinical Manifestation of Progressive Supranuclear Palsy
BACKGROUND The clinical and pathological heterogeneity of progressive supranuclear palsy (PSP) is well established. Even with a well-defined clinical phenotype and a thorough laboratory workup, PSP can be misdiagnosed, especially in its early stages. CASE REPORT A 52-year-old woman, who we initially diagnosed with a behavioral variant of frontotemporal dementia developed parkinsonian features...
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months later because of fever up to 39.2 ° C. On neurological examination, he was fully conscious but apathic and had little vigor. He also had impaired concreteness in thinking, slowed information processing and decreased verbal fluency. He had apparent dementia and scored 14/30 points on HDS-R (Hasegawa Dementia Rating Scale – Revised) showing disturbance in orientation, recent memory, and wo...
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Two patients with "pure akinesia" who showed the characteristic changes of progressive supranuclear palsy (PSP) at necropsy are described. They had akinesia but no rigidity or tremor, and ophthalmoplegia was not observed during the course of illness. The symptoms of "pure akinesia" was not improved by levodopa therapy but was considerably improved by L-threo-3,4-dihydroxy-phenylserine. At necro...
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Recent studies have shown that progressive supranuclear palsy (PSP) could be inherited, but the pattern of inheritance and the spectrum of the clinical findings in relatives are unknown. We here report 12 pedigrees, confirmed by pathology in four probands, with familial PSP. Pathological diagnosis was confirmed according to recently reported internationally agreed criteria. The spectrum of the ...
متن کاملClinical Approach to Progressive Supranuclear Palsy
Sixty years ago, Steele, Richardson and Olszewski designated progressive supranuclear palsy (PSP) as a new clinicopathological entity in their seminal paper. Since then, in addition to the classic Richardson's syndrome (RS), different clinical phenotypic presentations have been linked with this four-repeat tauopathy. The clinical heterogeneity is associated with variability of regional distribu...
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ژورنال
عنوان ژورنال: Journal of Clinical Neurology
سال: 2010
ISSN: 1738-6586
DOI: 10.3988/jcn.2010.6.3.148